DNA-binding proteins are proteins that are composed of DNA-binding domains and thus have a specific or general affinity for either single or double stranded DNA. Sequence-specific DNA-binding proteins generally interact with the major groove of B-DNA, because it exposes more functional groups that identify a base pair. However there are some known minor groove DNA-binding ligands such as Netropsin, Distamycin, Hoechst 33258, Pentamidine and others.
Read more about DNA-binding Proteins: Examples, Non-specific DNA-protein Interactions, DNA-binding Proteins That Specifically Bind Single-stranded DNA, Binding To Particular DNA Sequences
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