Disruptor can mean:
- An energy weapon in Star Trek
- An energy weapon in Star Wars
- See Dazzler (weapon) for a real weapon called a "disruptor"
- A video game for the Sony PlayStation by Insomniac Games
- CD-title from Remyl
- Endocrine disruptor
- A weapon on Lego Mars Mission, Ion Disruptor
- A handheld personality-wiping device from the television show Dollhouse
- A weapon used in bomb disposal that fires a jet of water to destroy an explosive device