Mechanism of Action
Unknown. In vitro experiments have shown that Au(I) can inhibit lymphocyte proliferation, lysosomal enzyme release, the release of reactive oxygen species from macrophages, and IL-1 production.
Gold salts can decrease the inflammation of the joint lining. This effect can prevent destruction of bone and cartilage. In former times gold salts were used as second-line drugs (used when the arthritis progressed in spite of antiinflammatory drugs). Nowadays such former "second-line" drugs are used from the beginning of therapy to inhibit joint erosion if possible.
Read more about this topic: Disodium Aurothiomalate
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