The Angiotensin II Receptor
The actions of Ang II are mediated by angiotensin receptors, AT1 and AT2. These receptors are members of the G protein-coupled receptors family which are seven transmembrane helices, connected by interchanging extracellular and intracellular loops.
Each G protein-coupled receptor couples to a specific G-protein which leads to activation of a special effector system. AT1 receptors are for instance primarily coupled through the Gq/11 group of G-proteins.
Two more angiotensin receptors have been described, AT3 and AT4, but their role is still unknown.
Read more about this topic: Discovery And Development Of Angiotensin Receptor Blockers
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