Protein Structure and Subcellular Distribution
The protein encoded by this gene, is predicted to contain a coiled coil motif rich C-terminal domain and a N-terminal globular domain. The N-terminus contains two putative nuclear localization signals and a serine-phenylalanine-rich motif of unknown significance. The C-terminus contains multiple regions with coiled-coil forming potential and two leucine zippers that may mediate protein-protein interactions.
The protein locates to the nucleus, centrosome, cytoplasm, mitochondria, axons and synapses. Mitochondria are the predominant site of endogenous DISC1 expression, with at least two isoforms occupying internal mitochondrial locations. No known functional homologues exist for this protein in humans, although it does have broad homology to scaffold proteins. The DISC1 protein function appears to be highly diverse and its functional role in cellular processes is dependent upon the cellular domain it is located in. The presence or absence of certain protein interaction domains or targeting motifs may confer specific functions and influence sub cellular targeting, therefore it is probable that alternative splicing codetermines both the function and the intracellular location of DISC1.
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