Examples
Drugs belonging to this class are :
- sitagliptin (FDA approved 2006, marketed by Merck & Co. as Januvia),
- vildagliptin (EU approved 2007, marketed in the EU by Novartis as Galvus),
- saxagliptin (FDA approved in 2009, marketed as Onglyza),
- linagliptin (FDA approved in 2011, marketed as Trajenta by Eli Lilly Co and Boehringer Ingelheim),
- dutogliptin (being developed by Phenomix Corporation), Phase III
- gemigliptin (being developed by LG Life Sciences,Korea)
- alogliptin (developed by Takeda Pharmaceutical Company, whose FDA application for the product is currently under review)
Berberine, the common herbal dietary supplement, too inhibits dipeptidyl peptidase-4, which at least partly explains its antihyperglycemic activity.
Read more about this topic: Dipeptidyl Peptidase-4 Inhibitors
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