Synthesis
DES was first synthesized in early 1938 by Leon Golberg, then a graduate student of Sir Robert Robinson at the Dyson Perrins Laboratory at the University of Oxford, based on a formulation of Wilfrid Lawson at the Courtand Institute of Biochemistry, led by Sir Edward Charles Dodds at Middlesex Hospital Medical School now part of University College London, and a report of its synthesis was published in Nature on 5 February 1938.
DES was first synthesized by English university research funded by the MRC, which had a policy against patenting drugs discovered using public funds. Because it was not patented, DES was produced by more than 200 pharmaceutical and chemical companies worldwide.
Read more about this topic: Diethylstilbestrol
Famous quotes containing the word synthesis:
“Our art is the finest, the noblest, the most suggestive, for it is the synthesis of all the arts. Sculpture, painting, literature, elocution, architecture, and music are its natural tools. But while it needs all of those artistic manifestations in order to be its whole self, it asks of its priest or priestess one indispensable virtue: “faith.””
—Sarah Bernhardt (1845–1923)
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—Jean Szarkowski (b. 1925)
“The spider-mind acquires a faculty of memory, and, with it, a singular skill of analysis and synthesis, taking apart and putting together in different relations the meshes of its trap. Man had in the beginning no power of analysis or synthesis approaching that of the spider, or even of the honey-bee; but he had acute sensibility to the higher forces.”
—Henry Brooks Adams (1838–1918)