| Gene Ontology | |
|---|---|
| Molecular function | • fatty-acyl-CoA binding • lipid binding • benzodiazepine receptor binding |
| Cellular component | • mitochondrion • endoplasmic reticulum • Golgi apparatus |
| Biological process | • hair follicle development • triglyceride metabolic process • transport • skin development |
| Sources: Amigo / QuickGO | |
120.12 – 120.13 Mb
120.11 – 120.12 Mb
Acyl-CoA-binding protein is a protein that in humans is encoded by the DBI gene.
This gene encodes diazepam binding inhibitor, a protein that is regulated by hormones and is involved in lipid metabolism and the displacement of beta-carbolines and benzodiazepines, which modulate signal transduction at type A gamma-aminobutyric acid receptors located in brain synapses. The protein is conserved from yeast to mammals, with the most highly conserved domain consisting of seven contiguous residues that constitute the hydrophobic binding site for medium- and long-chain acyl-Coenzyme A esters. Diazepam binding inhibitor also mediates the feedback regulation of pancreatic secretion and the postprandial release of cholecystokinin, in addition to its role as a mediator in corticotropin-dependent synthesis of steroids in the adrenal gland.
Three pseudogenes located on chromosomes 6, 8 and 16 have been identified. Multiple transcript variants encoding different isoforms have also been described for this gene.
Famous quotes containing the word binding:
“What is lawful is not binding only on some and not binding on others. Lawfulness extends everywhere, through the wide-ruling air and the boundless light of the sky.”
—Empedocles 484–424 B.C., Greek philosopher. The Presocratics, p. 142, ed. Philip Wheelwright, The Bobbs-Merrill Co., Inc. (1960)