DHI may refer to:
- DHI Water & Environment, a research, consulting and software organisation from Denmark
- Deutsches Historisches Institut, the German Historical Institutes present in several international cities
- Dhangarhi Airport (IATA airport code), Dhangarhi, Nepal
- Dhimal language (ISO 639-3 language code), a language spoken by the Dhimal people in Nepal and India
- Druk Holding and Investments, a holding company owned by the Government of Bhutan
- EMD DHI, an experimental diesel-hydraulic railroad locomotive
- 5,6-dihydroxyindole, a chemical compound constituent of melanin