DHC may refer to:
- Daigaku Honyaku Center, a Japanese manufacturer of cosmetics and health foods
- Dalian Hi-Think Computer, a Chinese outsourcing company
- Dance Hall Crashers, a popular Ska punk band
- Dance House Children, an early 1990s musical collaboration
- Dark Horse Comics
- de Havilland Canada, a defunct aircraft manufacturer:
- DHC-1 Chipmunk
- DHC-2 Beaver
- DHC-3 Otter
- DHC-4 Caribou
- DHC-5 Buffalo
- DHC-6 Twin Otter
- DHC-7 Dash 7
- DHC-8 Dash 8
- Destiny Hope Cyrus, the real name of Miley Cyrus
- Detroit Housing Commission, provider of public housing for the City of Detroit
- Digital hardcore, a music genre fusing elements of hardcore punk and various forms of electronic music
- Dihydrocodeine, a semi-synthetic opioid
- Dihydrocapsaicin, a capsaicinoid occurring in pepper
- Dihydrochalcone, a chemical compound
- Diocese of the Holy Cross, a medium sized jurisdiction in the Anglican Continuum
- Discovery Health Channel a part of the Discovery channel packet
- Drop-Head Coupe, a British term for a convertible car
- Dudley Hewitt Cup, the Central Canadian championship of the Canadian Junior A Hockey League
- Xerxes/DHC, a former Dutch professional football team