DGS may refer to:
- DiGeorge syndrome, a syndrome caused by the deletion of a small piece of chromosome 22
- D. G. S. Dhinakaran, Indian Christian evangelist
- German Sign Language (German: Deutsche Gebärdensprache)
- Diocesan Girls' School in Hong Kong
- Downers Grove South, a USA high school
- Dragon Go Server, an Internet Go server for correspondence Go
- German Society for Sociology (German: Deutsche Gesellschaft für Soziologie)
- Dartford Grammar School, an English secondary school
- Department of General Services (disambiguation), various US local agencies
- Deposit-guarantee scheme, a scheme for deposit-insurance, see Deposit insurance
- Degree of General science