Desiderius is a Latin given name which means "the longed-for". It may refer to:
- Desiderius (died circa 786), the last king of the Lombard Kingdom of northern Italy
- Desiderius, Abbot of Monte Cassino (circa 1026-1087), successor of Pope Gregory VII
- Desiderius Erasmus (circa 1466-1536), Dutch humanist and theologian
- Desiderius of Aquitaine (died 587), Gallo-Roman dux in the Kingdom of the Franks
- Desiderius of Fontenelle (died circa 700), Frankish saint
- Desiderius Wein (1873-1944), Hungarian doctor and gymnast