Dero may refer to:
- DJ Dero, Argentine DJ, producer and remixer of electronic music
- Dero Goi, a German musician
- Derro or Dero, Australian slang for a derelict person
- Al DeRogatis, American football player and announcer
- Jim DeRogatis, American rock music critic
- Mark DeRosa, American baseball player
- Dwayne De Rosario, Canadian Soccer player for D.C. United
- Dero, "detrimental robots" in the writing of Richard Sharpe Shaver
- Dero, one of the Nereids in Greek mythology
- Dero, backing emcee of The Infomatics
- DeRo, the pairing of Deniz and Roman on Alles was zählt
- Dero, the caste in Pakistan, mostly in Sindh Province, whose native language is Sindhi.
- DERO, the Unilever's laundry detergent trade mark used in Romania. DERO comes from "Detergent Românesc" (Romanian Detergent).
- DERO or DEROS, abbreviation of Date of Expected (or Estimated) Return from Overseas, US military slang
- Dero!, a Japanese gameshow
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