Deinococcus Radiodurans - Applications

Applications

Deinococcus has been genetically engineered for use in bioremediation to consume and digest solvents and heavy metals, even in a highly radioactive site. For example, the bacterial mercuric reductase gene has been cloned from Escherichia coli into Deinococcus to detoxify the ionic mercury residue frequently found in radioactive waste generated from nuclear weapons manufacture. Those researchers developed a strain of Deinococcus that could detoxify both mercury and toluene in mixed radioactive wastes.

The Craig Venter Institute has used a system derived from the rapid DNA repair mechanisms of D. radiodurans to assemble synthetic DNA fragments into chromosomes, with the ultimate goal of producing a synthetic organism they call Mycoplasma laboratorium.

In 2003, U.S. scientists demonstrated D. radiodurans could be used as a means of information storage that might survive a nuclear catastrophe. They translated the song It's a Small World into a series of DNA segments 150 base pairs long, inserted these into the bacteria, and were able to retrieve them without errors 100 bacterial generations later. However, since only a small portion of the information can be stored in DNA of D. radiodurans, several species had to be created, each holding a different part of the song and species needed to be kept segregated over time. If species are evolving together after a number of generations certain species will emerge dominant and others will become extinct and parts of the encoded message which were stored in extinct species will be lost.

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