Degrassi may refer to:
- Degrassi (franchise), a television fictional universe and franchise consisting of:
- The Kids of Degrassi Street, the original television series (1979–1986)
- Degrassi Junior High, the second series in the franchise (1987–1989)
- Degrassi High, the third series in the franchise, a direct continuation from Degrassi Junior High (1989–1991)
- Degrassi: The Next Generation, renamed Degrassi in the tenth season, the fourth series in the franchise, with a new generation of characters (2001–present)
- Degrassi Community School, the centric school, often referred to as "Degrassi" in universe
- Degrassi (band), a Scottish indie rock band
- "Degrassi", a song by Lemon Demon
- Attilio Degrassi (1887–1969), an Italian scholar of Latin epigraphy