Debus is a French name in origin. It is commonly used as a surname and may refer to:
- Allen G. Debus (born 1926), American historian of science
- Bob Debus (born 1943), Australian politician
- Jon Debus (born 1958), player, coach and manager in Minor League Baseball
- Kurt H. Debus, NASA official
- Debus (crater), a crater on the far side of the moon named for Kurt Debus
- Debus (martial art), a martial art from Banten, Indonesia