Binding and Interactions
Death-fold motifs are believed to exert their effects solely through monovalent, homotypic interactions. In these interactions death-folds bind to another death-fold containing domain through the same type of protein interaction domain. These interactions are highly specific, and there are no known interactions between different types of death-fold domains - in every known case the binding partners have homologous domain (DD-DD, CARD-CARD, DED-DED). The role of these homotypic interactions is thought to be self-assembly (Lahm). This results in large multi-subunit structures made of only one type of protein.
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Famous quotes containing the words binding and/or interactions:
“What is lawful is not binding only on some and not binding on others. Lawfulness extends everywhere, through the wide-ruling air and the boundless light of the sky.”
—Empedocles 484–424 B.C., Greek philosopher. The Presocratics, p. 142, ed. Philip Wheelwright, The Bobbs-Merrill Co., Inc. (1960)
“In our interactions with people, a benevolent hypocrisy is frequently required—acting as though we do not see through the motives of their actions.”
—Friedrich Nietzsche (1844–1900)