Binding and Interactions
Death-fold motifs are believed to exert their effects solely through monovalent, homotypic interactions. In these interactions death-folds bind to another death-fold containing domain through the same type of protein interaction domain. These interactions are highly specific, and there are no known interactions between different types of death-fold domains - in every known case the binding partners have homologous domain (DD-DD, CARD-CARD, DED-DED). The role of these homotypic interactions is thought to be self-assembly (Lahm). This results in large multi-subunit structures made of only one type of protein.
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Famous quotes containing the words binding and/or interactions:
“What is lawful is not binding only on some and not binding on others. Lawfulness extends everywhere, through the wide-ruling air and the boundless light of the sky.”
—Empedocles 484–424 B.C., Greek philosopher. The Presocratics, p. 142, ed. Philip Wheelwright, The Bobbs-Merrill Co., Inc. (1960)
“The exercise of power is determined by thousands of interactions between the world of the powerful and that of the powerless, all the more so because these worlds are never divided by a sharp line: everyone has a small part of himself in both.”
—Václav Havel (b. 1936)