De Los Santos is a common surname in the Spanish language meaning of the saints.
- Epifanio de los Santos (1871–1928), Filipino historian
- Gonzalo de los Santos (born 1976), Uruguayan football player
- Jaime de los Santos (born 1946), Filipino general
- Ramón de los Santos (born 1949), Dominican Republic baseball player
De Los Santos may also refer to:
- Epifanio de los Santos Avenue
Fiction may also refer to:
- Santiago de los Santos, a character in Noli Me Tangere of the Filipino hero, Jose Rizal
Famous quotes containing the word los:
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—Joan Didion (b. 1935)