De Boer, de Boer, and variants thereof, are Dutch surnames, deriving from the Dutch word for "farmer", boer, and which belong to the following people:
- Ad de Boer, Dutch politician and journalist
- Ale de Boer (born 1987), Dutch footballer
- Arthur DeBoer, American doctor
- Betty de Boer, Dutch politician
- Brent De Boer, drummer and backup vocalist with The Dandy Warhols
- Frank de Boer (born 1970), Dutch football defender
- Hannes de Boer, Dutch athlete
- Harry DeBoer, American labor activist
- Jan de Boer, Dutch gymnast
- Jan Hendrik de Boer, Dutch scientist
- Jelle Taeke de Boer (1908–1970), Dutch art collector
- Johanna de Boer, Dutch fencer
- Johannes de Boer, German soldier
- Kalen DeBoer, American footballer
- Klaas de Boer, U.S. footballer
- Lieuwe de Boer, Dutch speed skater
- Margreeth de Boer, Dutch politician
- Matt de Boer, Australian rules footballer
- Mickey de Boer, Dutch international cricketer
- Mieke de Boer, Dutch darts player
- Nicole de Boer (born 1970), Canadian actress
- Peter DeBoer, Canadian hockey player
- Remmelt de Boer, Dutch educator and politician
- René de Boer (born 1945), Dutch sculptor
- Roelf de Boer, Dutch politician
- Ronald de Boer (born 1970), Dutch football midfielder
- Saco Rienk DeBoer, Dutch architect
- Ted De Boer (1921–2004), the Founder of the National Inventors Foundation
- Wubbo de Boer, Dutch civil servant
- Yoann de Boer (born 1982), Dutch football midfielder
- Yvo de Boer, the current Executive Secretary of the United Nations Framework Convention on Climate Change