Baltimore Orioles
Knowles signed with the Baltimore Orioles in 1961 after attending the University of Missouri. He spent four seasons in their farm system, going 45-28 with a 2.83 earned run average, mostly as a starter. He made his debut with the Orioles in 1965, pitching 1.2 innings out of the bullpen, and giving up five earned runs before returning to the triple A Rochester Red Wings. Upon completion of the International League season, Knowles received a September call back up to Baltimore. He went 0-1 with a 6.92 ERA in his return. The loss came against the Detroit Tigers in his only start.
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