Filmography
| Year | Title | Role | Notes |
|---|---|---|---|
| 1985 | Runaway Train | Boxer | |
| 1987 | Penitentiary III | See Veer | |
| The Hidden | Prisoner | ||
| Death Wish 4: The Crackdown | Art Sanella | ||
| 1988 | Bulletproof | Sharkey | |
| 1989 | Kinjite: Forbidden Subjects | Prison Inmate | |
| Lock Up | Chink's Gang Member | ||
| Bail Out | Mean | a.k.a. W.B., Blue and the Bean | |
| Cage | Costello's Bodyguard | ||
| 1990 | Drug Wars: The Camarena Story | Gabriel | TV mini-series |
| Guns | Tong | ||
| Maniac Cop 2 | Prisoner | ||
| Marked for Death | Hector | ||
| 1991 | The Last Hour | Spider | |
| Mi Vida Loca | Frank/Casual Dreamer | ||
| Whore | Tattoo Artist | ||
| Wedlock | Tough Prisoner #1 | ||
| Femme Fatale | Toshi | ||
| Carnal Crimes | Chandra | ||
| Lonely Hearts | Angry Client | ||
| Baywatch | Carlos Urueta | TV; episode Point of Attack | |
| 1992 | Reasonable Doubts | Cholo #2 | TV; episode The Shadow of Death |
| Nails | Las Virgenes bartender | TV film | |
| Baywatch | Chulo | TV; episode Masquerade | |
| 1993 | Sunset Grill | Young Mexican | |
| Blood in Blood Out | Geronimo | a.k.a. Bound by Honor | |
| Doppelganger | Hard Hat | ||
| Mi Vida Loca | Frank | ||
| 12:01 | Prisoner | TV film | |
| Last Light | 2nd Inmate | ||
| Love, Cheat & Steal | Cuban | ||
| 1994 | Criminal Passion | Construction Worker | |
| Against The Wall | Luis | TV film | |
| 1995 | Dead Badge | El Tango Bartender | |
| The Stranger | Hawk | ||
| Desperado | Navajas | ||
| Fallen Angels | Boxer | TV; episode Love and Blood | |
| Heat | Trejo | ||
| 1996 | From Dusk till Dawn | Razor Charlie | |
| Renegade | Freddie | TV; episode Hog Calls | |
| NYPD Blue | Gabriel Mota | TV; episode Hollie and the Blowfish | |
| Le Jaguar | Kumare | ||
| 1997 | Los Locos | Manuel Batista | |
| Anaconda | Poacher | ||
| Con Air | Johnny 23 | ||
| Trojan War | Scarface | ||
| Dilemma | Rudy Salazar | ||
| 1998 | Tracey Takes On... | Hispanic Man | TV; two episodes |
| Brooklyn South | Louis | TV; episode Skel in a Cell | |
| Walker, Texas Ranger | Joe Lopez | TV; episode Circle of Life | |
| Point Blank | Wallace | ||
| The Replacement Killers | Collins | ||
| Six Days Seven Nights | Pierce | ||
| Champions | Max Brito | ||
| Soundman | Duce's Father | ||
| NYPD Blue | Frankie Soto | TV; episode Numb & Number | |
| 1999 | From Dusk till Dawn 2: Texas Blood Money | Razor Eddie | |
| Inferno | Johnny Six Toes | a.k.a. Desert Heat | |
| Walker, Texas Ranger | José Rodriguez | TV; episode Rise to the Occasion | |
| 2000 | From Dusk till Dawn 3: The Hangman's Daughter | Razor Charlie | |
| Animal Factory | Vito | ||
| Reindeer Games | Jumpy | ||
| The X-Files | Spider-Man/Cesar Ocampo | TV; episode Redrum | |
| 2001 | Spy Kids | Isador "Machete" Cortez | |
| Bubble Boy | Slim | ||
| Skippy | Hitman | ||
| 2002 | 13 Moons | Hoodlum #2 | |
| The Salton Sea | Little Bill | ||
| Do It for Uncle Manny | Pedro | ||
| The District | Danny | TV; episode Convictions | |
| Spy Kids 2: The Island of Lost Dreams | Isador "Machete" Cortez | ||
| xXx | El Jefe | ||
| Grand Theft Auto: Vice City | Umberto Robina (voice only) | video game | |
| The Hire: Beat the Devil | Bob | short film | |
| Nightstalker | Officer Frank Luis | ||
| 2003 | Spy Kids 3-D: Game Over | Machete | |
| Once Upon a Time in Mexico | Cucuy | ||
| Kingpin | Manny | TV mini-series | |
| Alias | Emilio Vargas | TV; episode Countdown | |
| The Brothers García | Eduardo 'Ed' Garcia | TV; episode It Was Fun While It Lasted | |
| Double Blade | El Patron | short film | |
| King of the Hill | Enrique (voice only) | TV; 17 episodes; 2003–2010 | |
| 2004 | Anchorman: The Legend of Ron Burgundy | Bartender | |
| Def Jam: Fight for NY | Trejo (voice only) | video game | |
| Lost | Edward James Archer | ||
| Grounded for Life | Raul | TV; episode (She's Got) Kegs | |
| Monk | Spyder Rudner | TV; episode Mr. Monk Goes to Jail | |
| Wake Up, Ron Burgundy: The Lost Movie | Bartender | ||
| 2005 | All Souls Day | Vargas Diaz | a.k.a. All Souls Day: Dia de los Muertos |
| Tennis, Anyone...? | Hector | ||
| The Curse of El Charro | El Charro (voice only) | ||
| George Lopez | Bobby | TV; episode George's Extreme Makeover: Holmes Edition | |
| Chasing Ghosts | Carlos Santiago | ||
| High Hopes | Shady | formerly Nice Guys | |
| Champion. | Himself | ||
| The Devil's Rejects | Rondo | ||
| The Crow: Wicked Prayer | Harold | A catholic-Indian priest, chief of a Puerto-Rican gang. | |
| Venice Underground | Papi | ||
| Dreaming on Christmas | Train Driver | ||
| Desperate Housewives | Hector Ramos | TV; episode The Sun Won't Set | |
| 2006 | Furnace | Fury | |
| TV: The Movie | Crow | ||
| Propensity | Roy | ||
| Sherrybaby | Dean Walker | ||
| Living the Dream | Chuck | ||
| Danny Roane: First Time Director | Hector | ||
| Heist | Ernesto | TV; episode How Billy Got His Groove Back | |
| Grand Theft Auto: Vice City Stories | Umberto Robina (voice only) | video game | |
| Hood of Horror | Derelict | a.k.a. Snoop Dogg's Hood of Horror | |
| Seven Mummies | Apache | ||
| Slayer | Montegna | TV film | |
| Haunted Prison | Priest | ||
| 2007 | Smiley Face | Albert | |
| Grindhouse | Machete | segment: Machete | |
| Delta Farce | Carlos Santana | ||
| The Knights of Prosperity | Hector | TV; episode Operation: Open the Safe | |
| Halloween | Ismael Cruz | ||
| Battle for Terra | Elder Barum (voice only) | ||
| The Blue Rose | Junk | ||
| Urban Justice | El Chivo | ||
| Stargate: Atlantis | Omal | TV; episode Missing | |
| On Bloody Sunday | The Ref | ||
| Blood Ties | Pacha Kamaq | TV; episode Wrapped | |
| 2008 | Valley of Angels | Hector | |
| Through the Valley | Don Reyes | ||
| Richard III | Major | ||
| The Art of Travel | Limo Driver | ||
| I Am Somebody: No Chance in Hell | Malono | ||
| Jake's Corner | Clint | ||
| Ranchero | Capone | ||
| Toxic | Antoine | ||
| Alone in the Dark II | Perry | ||
| La Linea | Mario | ||
| Necessary Evil | Barro | ||
| The Young and the Restless | Bartender | TV; 15 episodes | |
| 2009 | The Grind | Nicholi Guzman | |
| Fanboys | The Chief | ||
| The Spectacular Spider-Man | Ox (voice only) | TV; episode "Probable Cause" | |
| The Haunted World of El Superbeasto | Rico (voice only) | ||
| Modus Operandi | Director Holiday | ||
| The Boys of Ghost Town | Father | ||
| Eyeborgs | G-Man | ||
| Breaking Bad | Tortuga | TV; episode Negro Y Azul | |
| 2010 | The Killing Jar | Jimmy | |
| The Lazarus Papers | Aroon | ||
| Shoot the Hero | Crazy Joe | ||
| Burn Notice | Vega | TV; episode Friendly Fire | |
| Breaking Bad | Tortuga | TV; episodes I.F.T. and Negro y Azul | |
| Shadows in Paradise | Matador | ||
| Boston Girls | Uncle Reggie | ||
| Pastor Shepherd | Phil Harrison | ||
| Saint John of Las Vegas | Bismarck | ||
| The Bill Collector | Uncle Frankie | ||
| Lean Like a Cholo | The O.G. | ||
| Fallout: New Vegas | Raul Alfonso Tejada | Video game | |
| Food Stamps | Mr. Fernandez | ||
| Sebring feat. Danny Trejo | Danny Trejo | Do IT LIVE webisode, season 1 | |
| Bones | Bishop | Finder | |
| Dark Games | Archie | ||
| Project x27 | Mondo | ||
| Tim and Eric Awesome Show, Great Job! | Suspect | TV; episode Comedy | |
| The Good Guys | Mexican Drug Dealer | ||
| Predators | Cuchillo | ||
| North by El Norte | Uncle John | ||
| Beatdown | Marcus | Direct-to-DVD | |
| Machete | Machete Cortez | first leading role | |
| Justin Time | Mardok | ||
| The Fight: Lights Out | As a trainer named Duke | Video game | |
| Modern Family | Gus | TV; episode Dance Dance Revelation | |
| 2011 | Young Justice | Bane | Voice |
| Death Race 2 | Goldberg | Direct-to-DVD | |
| Call of Duty: Black Ops | Himself | Video game. In the zombie map Call of the Dead | |
| Franklin & Bash | "Ultimo" A professional Wrestler | TV Series | |
| Spy Kids 4: All the Time in the World | Isador "Machete" Cortez | ||
| Violet & Daisy | Russ | ||
| A Very Harold & Kumar 3D Christmas | Mr. Perez | Harold's father-in-law | |
| Vengeance | Jack | ||
| House of the Rising Sun | Carlos | ||
| Sons of Anarchy | Romeo Parada | TV Series, FX (TV Channel), Season 4 | |
| Haunted High School | Mortiz | ||
| 2012 | Bad Ass | Frank Vega | Inspired by Tom Bruso |
| Breaking Wind | Billy Black | A comedic spoof based on the Twilight Saga | |
| Mango Bajito | Carson | Independent Spanish language film | |
| Sons of Anarchy | Romeo Parada | TV Series, FX (TV Channel), Season 5 | |
| Recoil | Drayke Salgado | ||
| 2013 | Machete Kills | Machete Cortez | Sequel to Machete |
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