Genetic Basis of Variability
The genetic basis for extensive and poor metaboliser variability is the CYP2D6 allele, located on chromosome 22. Subjects possessing certain allelic variants will show normal, decreased, or no CYP2D6 function, depending on the allele.
| CYP2D6 allele and enzyme activity | |
| Allele | CYP2D6 activity |
| CYP2D6*1 | normal |
| CYP2D6*2 | increased |
| CYP2D6*3 | none |
| CYP2D6*4 | none |
| CYP2D6*5 | none |
| CYP2D6*9 | decreased |
| CYP2D6*10 | decreased |
| CYP2D6*17 | decreased |
Read more about this topic: CYP2D6
Famous quotes containing the words genetic, basis and/or variability:
“We cannot think of a legitimate argument why ... whites and blacks need be affected by the knowledge that an aggregate difference in measured intelligence is genetic instead of environmental.... Given a chance, each clan ... will encounter the world with confidence in its own worth and, most importantly, will be unconcerned about comparing its accomplishments line-by-line with those of any other clan. This is wise ethnocentricism.”
—Richard Herrnstein (1930–1994)
“Protoplasm, simple or nucleated, is the formal basis of all life. It is the clay of the potter: which, bake it and paint it as he will, remains clay, separated by artifice, and not by nature from the commonest brick or sun-dried clod.”
—Thomas Henry Huxley (1825–1895)
“The grand points in human nature are the same to-day they were a thousand years ago. The only variability in them is in expression, not in feature.”
—Herman Melville (1819–1891)