Role in Disease
Dysregulation of this enzyme has been implicated in several neurodegenerative diseases including Alzheimer's.
It is involved in invasive cancers, apparently by reducing the activity of the actin regulatory protein caldesmon.
Read more about this topic: Cyclin-dependent Kinase 5
Famous quotes containing the words role in, role and/or disease:
“Language makes it possible for a child to incorporate his parents’ verbal prohibitions, to make them part of himself....We don’t speak of a conscience yet in the child who is just acquiring language, but we can see very clearly how language plays an indispensable role in the formation of conscience. In fact, the moral achievement of man, the whole complex of factors that go into the organization of conscience is very largely based upon language.”
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“Of course, some men are very effective caregivers [of elderly parents]. But this situation occurs far less frequently for males than females, because it is a role reversal. For women, caregiving is an expected duty; for men, it is an unexpected expression of love or devotion.”
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“It is the disease of not listening, the malady of not marking,
that I am troubled withal.”
—William Shakespeare (1564–1616)