Cyclin-dependent Kinase 5

Cyclin-dependent Kinase 5

Identifiers Symbols CDK5; PSSALRE External IDs OMIM: 123831 MGI: 101765 HomoloGene: 3623 ChEMBL: 4036 GeneCards: CDK5 Gene EC number 2.7.11.22

Gene Ontology
Molecular function	• p53 binding • protein kinase activity • protein serine/threonine kinase activity • cyclin-dependent protein kinase activity • ErbB-2 class receptor binding • protein binding • ATP binding • kinase activity • acetylcholine receptor activator activity • ErbB-3 class receptor binding • tau-protein kinase activity
Cellular component	• nucleus • cytoplasm • cytosol • plasma membrane • postsynaptic density • membrane • cyclin-dependent protein kinase 5 holoenzyme complex • lamellipodium • cell junction • filopodium • axon • dendrite • growth cone • neuromuscular junction • neuronal cell body • perikaryon • postsynaptic membrane
Biological process	• neuron migration • synaptic transmission, dopaminergic • intracellular protein transport • nucleocytoplasmic transport • cell-matrix adhesion • synaptic transmission • axon guidance • synapse assembly • skeletal muscle tissue development • blood coagulation • motor neuron axon guidance • cell proliferation • visual learning • embryo development • Schwann cell development • synaptic vesicle exocytosis • phosphorylation • peptidyl-serine phosphorylation • peptidyl-threonine phosphorylation • sensory perception of pain • cerebellar cortex formation • hippocampus development • layer formation in cerebral cortex • central nervous system neuron development • corpus callosum development • neuron differentiation • regulation of cell migration • cortical actin cytoskeleton organization • neuron projection development • negative regulation of protein ubiquitination • negative regulation of synaptic plasticity • positive regulation of protein binding • receptor catabolic process • serine phosphorylation of STAT3 protein • synaptic transmission, glutamatergic • protein localization to synapse • regulation of apoptotic process • receptor clustering • positive regulation of neuron apoptotic process • regulated secretory pathway • negative regulation of cell cycle • positive regulation of protein kinase activity • negative regulation of transcription, DNA-dependent • positive regulation of calcium ion-dependent exocytosis • protein autophosphorylation • negative regulation of protein export from nucleus • behavioral response to cocaine • regulation of synaptic plasticity • synaptic vesicle endocytosis • axon extension • oligodendrocyte differentiation • dendrite morphogenesis • cell division • neuron apoptotic process • regulation of excitatory postsynaptic membrane potential • regulation of dendritic spine morphogenesis • calcium ion import • regulation of cell cycle arrest • positive regulation of protein targeting to membrane • positive regulation of actin cytoskeleton reorganization
Sources: Amigo / QuickGO

RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 1020 12568 Ensembl ENSG00000164885 ENSMUSG00000028969 UniProt Q00535 P49615 RefSeq (mRNA) NM_001164410 NM_007668 RefSeq (protein) NP_001157882 NP_031694 Location (UCSC) Chr 7:
150.75 – 150.76 Mb Chr 5:
24.42 – 24.42 Mb PubMed search

Cell division protein kinase 5 is an enzyme that in humans is encoded by the CDK5 gene. The protein encoded by this gene is part of the cyclin-dependent kinase family.