Cyclin-dependent Kinase - Types

Types

Table 1: Known CDKs, their cyclin partners, and their functions in the human and consequences of deletion in mice.

CDK Cyclin partner Function Deletion Phenotype in Mice
Cdk1 Cyclin B M phase None. ~E2.5.
Cdk2 Cyclin E G1/S transition Reduced size, imparted neural progenitor cell proliferation. Viable, but both males & females sterile.
Cdk2 Cyclin A S phase, G2 phase
Cdk3 Cyclin C G1 phase ? No defects. Viable, fertile.
Cdk4 Cyclin D G1 phase Reduced size, insulin deficient diabetes. Viable, but both male & female infertile.
Cdk5 p35 Transcription Severe neurological defects. Died immediately after birth.
Cdk6 Cyclin D G1 phase
Cdk7 Cyclin H CDK-activating kinase, transcription
Cdk8 Cyclin C Transcription
Cdk9 Cyclin T Transcription Embryonic lethal
Cdk11 Cyclin L ? Mitotic defects. E3.5.
? Cyclin F ? Defects in extraembryonic tissues. E10.5.
? Cyclin G ?

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