Cuffy may refer to:
- Cuffy (person), or Kofi, an Akan slave in the Dutch colony of Berbice (present-day Guyana) who in 1763 led a revolt of more than 2,500 slaves
- Cuffy, Cher, a commune of the Cher département, in France
- Cuffy (TV series), a British sitcom from the early 1980s.
- Cuffy Meigs, a character in Atlas Shrugged
See also:
- William Cuffay