CRYBB3

Identifiers Symbols CRYBB3; CATCN2; CRYB3 External IDs OMIM: 123630 MGI: 102717 HomoloGene: 3008 GeneCards: CRYBB3 Gene

Gene Ontology
Molecular function structural constituent of eye lens
Biological process visual perception
Sources: Amigo / QuickGO
RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 1417 12962 Ensembl ENSG00000100053 ENSMUSG00000029352 UniProt P26998 Q9JJU9 RefSeq (mRNA) NM_004076 NM_001159650 RefSeq (protein) NP_004067 NP_001153122 Location (UCSC) Chr 22:
25.6 – 25.6 Mb Chr 5:
113.08 – 113.08 Mb PubMed search

Beta-crystallin B3 is a protein that in humans is encoded by the CRYBB3 gene.

Crystallins are separated into two classes: taxon-specific, or enzyme, and ubiquitous. The latter class constitutes the major proteins of vertebrate eye lens and maintains the transparency and refractive index of the lens. Since lens central fiber cells lose their nuclei during development, these crystallins are made and then retained throughout life, making them extremely stable proteins. Mammalian lens crystallins are divided into alpha, beta, and gamma families; beta and gamma crystallins are also considered as a superfamily. Alpha and beta families are further divided into acidic and basic groups. Seven protein regions exist in crystallins: four homologous motifs, a connecting peptide, and N- and C-terminal extensions. Beta-crystallins, the most heterogeneous, differ by the presence of the C-terminal extension (present in the basic group, none in the acidic group). Beta-crystallins form aggregates of different sizes and are able to self-associate to form dimers or to form heterodimers with other beta-crystallins. This gene, a beta basic group member, is part of a gene cluster with beta-A4, beta-B1, and beta-B2.