CRYBB2

CRYBB2

Identifiers Symbols CRYBB2; CCA2; CRYB2; CRYB2A; D22S665 External IDs OMIM: 123620 MGI: 88519 HomoloGene: 420 GeneCards: CRYBB2 Gene

Gene Ontology
Molecular function structural molecule activity
structural constituent of eye lens
identical protein binding
protein homodimerization activity
Biological process visual perception
camera-type eye development
response to stimulus
Sources: Amigo / QuickGO
RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 1415 12961 Ensembl ENSG00000244752 ENSMUSG00000042240 UniProt P43320 P62696 RefSeq (mRNA) NM_000496 NM_007773 RefSeq (protein) NP_000487 NP_031799 Location (UCSC) Chr 22:
25.62 – 25.63 Mb Chr 5:
113.06 – 113.07 Mb PubMed search

Beta-crystallin B2 is a protein that in humans is encoded by the CRYBB2 gene.

Crystallins are separated into two classes: taxon-specific, or enzyme, and ubiquitous. The latter class constitutes the major proteins of vertebrate eye lens and maintains the transparency and refractive index of the lens. Since lens central fiber cells lose their nuclei during development, these crystallins are made and then retained throughout life, making them extremely stable proteins. Mammalian lens crystallins are divided into alpha, beta, and gamma families; beta and gamma crystallins are also considered as a superfamily. Alpha and beta families are further divided into acidic and basic groups. Seven protein regions exist in crystallins: four homologous motifs, a connecting peptide, and N- and C-terminal extensions. Beta-crystallins, the most heterogeneous, differ by the presence of the C-terminal extension (present in the basic group, none in the acidic group). Beta-crystallins form aggregates of different sizes and are able to self-associate to form dimers or to form heterodimers with other beta-crystallins. This gene, a beta basic group member, is part of a gene cluster with beta-A4, beta-B1, and beta-B3. A chain-terminating mutation was found to cause type 2 cerulean cataracts.

Read more about CRYBB2:  Interactions