Cruzeiro, generally the Portuguese language-term for Cross, can refer to:
- Brazilian cruzeiro, the former currency of Brazil
- Cruzeiro Esporte Clube, a Brazilian football team from the city of Belo Horizonte, Minas Gerais
- Cruzeiro Esporte Clube (RO), a Brazilian football team from the city of Porto Velho, Rondônia
- Cruzeiro Futebol Clube (BA), a Brazilian football team from the city of Cruz das Almas, Bahia
- Esporte Clube Cruzeiro, a Brazilian football team from the state of Rio Grande do Sul
- Serviços Aéreos Cruzeiro do Sul, a Brazilian aviation company founded in 1927 and absorbed into VARIG in 1993