Cell Biology
Antigen-presenting cells capable of cross-presentation are primarily dendritic cells, but macrophages, B lymphocytes and liver sinusoidal endothelial cells have also been shown to be able to do so. The intracellular mechanisms of cross-presentation are still unclear, but seem to involve specialized subcellular compartments bearing characteristics of both the endoplasmic reticulum and the endosome.
Endocytosed proteins are transported out of this compartment into the cytoplasm by unknown mechanisms. There they are processed by the proteasome into peptides, which are transported by the TAP transporter into the endoplasmic reticulum, or back into the same endosomes, where they associate with MHC class I molecules.
Finally, MHC class I - peptide complexes are transported to the cell surface, where they can be detected by specific CD8 T cells.
Read more about this topic: Cross-presentation
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