CRN may refer to:
- Center for Responsible Nanotechnology
- Climate Reference Network a network of climate stations in the United States for future long-term standardized observations
- Cognos Reportnet
- CREMe Research Network
- CRN, SIL code for the Cornish language
- CRN, station code for Crowthorne railway station in the United Kingdom
- Cable Radio Network, a distributor of talk radio programming to cable television outlets in the United States
- Course Reference Number (CRN)
- Cumann Rince Náisiúnta, an Irish Dancing organisation
- CRN, Amtrak station code for Creston, Iowa, United States
- CRN, ICAO airline designator for Empresa Aerocaribbean, Cuba
- CRN, cosmogenic radionuclides
- CrN, chromium nitride
- CRN Magazine, originally titled Computer Reseller News
- CRN, Customer Reference Number