Analogous Conditions in Other Animals
The MATP gene is highly conserved, especially among mammals. The human MATP gene is 82% identical to the mouse MATP gene, 79% identical to the rat MATP gene, 35% to the zebrafish version, and 30% identical to the fruitfly MATP gene. The gene is best known in humans as being the location of a mutation that results in human type IV oculocutaneous albinism (OCA4). Type IV oculocutaneous albinism, like other types of human albinism, results in hypopigmentation of the skin and eyes, with increased rates of skin cancer and reduced visual acuity. None of these effects are associated with the equine cream gene. Other human MATP polymorphisms result in normal pigment variations, specifically fair skin, light eyes, and light hair in Caucasian populations.
A polymorphism on the mouse MATP gene is known to be the cause of the underwhite coat color phenotype. The phenotype was first identified in the 1960s, and since then has been mapped successfully. Affected individuals have a reduction in eye and coat pigmentation, and irregularly shaped melanosomes.
Read more about this topic: Cream Gene, Inheritance and Expression
Famous quotes containing the words analogous, conditions and/or animals:
“It has become the custom in our country to expect all Chief Executives, from the President down, to conduct activities analogous to an entertainment bureau. No occasion is too trivial for its promoters to invite them to attend and deliver an address.”
—Calvin Coolidge (1872–1933)
“A society which is clamoring for choice, which is filled with many articulate groups, each urging its own brand of salvation, its own variety of economic philosophy, will give each new generation no peace until all have chosen or gone under, unable to bear the conditions of choice. The stress is in our civilization.”
—Margaret Mead (1901–1978)
“There is no instant of time when one creature is not being devoured by another. Over all these numerous races of animals man is placed, and his destructive hand spares nothing that lives. He kills to obtain food and he kills to clothe himself; he kills to adorn himself; he kills in order to attack and he kills to defend himself; he kills to instruct himself and he kills to amuse himself; he kills to kill. Proud and terrible king, he wants everything and nothing resists him.”
—Joseph De Maistre (1753–1821)