Clinical Significance
Several clinical phenomena result from injury to the corticopontine fibers. The corticopontine fibers to cranial nerves V and XII descend to bilateral nuclei. Injury to these fibers result in tongue weakness (cranial nerve XII) and jaw weakness (cranial nerve V) but not full paralysis. The corticopontine fibers to cranial nerve VII descend to innervate bilateral sub-nuclei that supply the forehead but only contralateral to the sub-nuclei that supply the lower face. Injury to these fibers results in paralysis of the lower face, but only weakness of the forehead.
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