Cortese is a surname of Italian origin. It may refer to:
- Anthony Cortese (b. 1947), US environmental scientist
- Bob Cortese (f. 1990s), US college football coach
- Dan Cortese (b. 1967), US actor
- Daniels Holderby Cortése (b. 1982), US operatic female singer
- David D. Cortese (f. 2000s), US political figure (Santa Clara County, California Supervisor)
- Deena Cortese American television personality, Jersey Shore
- Dominic L. Cortese (b. 1932), US political figure (California state legislator 1980–96)
- Enrico Cortese (b. 1985), Italian athlete in football
- Franco Cortese (1903–1986), Italian auto racing driver
- Genevieve Cortese (b. 1981), US television actress
- Giovanni Andrea Cortese (1483–1548), Italian cardinal and monastic reformer
- Giulio Cesare Cortese (1570-1640), Italian writer
- Guillaume Courtois (1628-1679), French-born artist who flourished in Rome, where he was known as Guglielmo Cortese
- Joseph Cortese (b. 1949), US actor
- Laura Cortese (f. 1990s-2000s), US female musician
- Leonardo Cortese (1916-1984), Italian film actor and director
- Pete Cortese (f. 1990s-2000s), US musician
- Sandro Cortese (b. 1990), German motorcycle racer
- Shane Cortese (b. 1968), New Zealand actor and singer
- Valentina Cortese (b. 1925), Italian actress
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