Variations
Although CBS catalyst 1 developed by Corey has become commonly employed in the CBS reduction reaction, other derivatives of the catalyst have been developed and utilized successfully. The R’ group of the CBS catalyst plays an important role in the enantioselectivity of the reduction, and as illustrated in above in the Scope section, several variations of the CBS R’ group have been employed to optimize selectivity.
Read more about this topic: Corey-Itsuno Reduction
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