Copperhead may refer to:
In Snakes:
- Agkistrodon contortrix, or copperhead, a venomous pit viper species found in parts of North America
- Austrelaps, or Australian copperhead, a genus of venomous elapids found in southern Australia and Tasmania
- Elaphe radiata, or the copperhead rat snake, a non-venomous species found in southern Asia
- Deinagkistrodon acutus, or the Chinese copperhead, a venomous pit viper species found in Southeast Asia
In Politics:
- Copperheads (politics), Northern Peace Democrats who opposed the American Civil War
In Fictional characters:
- "Copperhead", codename of Vernita Green in the movie Kill Bill
- Copperhead (Marvel Comics), several characters
- Copperhead (DC Comics), DC Comics supervillain and member of the Secret Society of Super-Villains
- Copperhead (G.I. Joe), villain in the G.I. Joe universe, member of Cobra
Other:
- Copperhead (film), a 2008 horror film
- Copperhead, the second volume in the U.S. Civil War series The Starbuck Chronicles by Bernard Cornwell
- Copperhead (climbing), a small metal nut used in rock climbing
- M712 Copperhead, a U.S. guided artillery shell
- Copperhead, a gaming mouse by Razer USA
- Dodge Copperhead, a more affordable, less-powerful model of the Dodge Viper, not produced
- Copperhead, a San Francisco area band of the early 1970s featuring John Cipollina