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- Samuel Cooper (disambiguation)
- Sarah Cooper (1848–1932), Victorian British Oxford-based marmalade maker
- Selina Cooper (1864–1946), English suffragist and politician
- Shane Cooper (disambiguation)
- Shaun Cooper (born 1983), English footballer
- Sheldon Cooper, fictional character from American TV sitcom The Big Bang Theory
- Sherry Cooper, Canadian-American, Chief Economist of BMO Capital Markets
- Shewell Cooper (1900–1982), organic gardener
- Simon Cooper (born 1936), British Army officer
- Sly Cooper (character), fictional character from the video game series Sly Cooper
- Stoney Cooper (1918–1977), American country musician
- Susan Cooper (disambiguation)
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