Isolation or Observation of The Conformational Isomers
- Atropoisomers can be quite stable depending on the steric effects and were the first conformational isomers to be identified. In the biphenylic system atropisomerism is especially prevalent, e.g. binaphthol.
- In cyclohexane derivatives, the two chair conformers interconvert with rates on the order of 105ring flips/sec, which obviously precludes their separation. The equatorial conformer crystallizes selectively, and when these crystals are dissolved at very low temperatures, one can directly monitor the approach to equilibrium by NMR spectroscopy.
Read more about this topic: Conformational Isomerism
Famous quotes containing the words isolation and/or observation:
“I am greatly pleased with the public, authentic isolation in which we two, you and I, now find ourselves. It is wholly in accord with our attitude and our principles.”
—Karl Marx (1818–1883)
“One man’s observation is another man’s closed book or flight of fancy.”
—Willard Van Orman Quine (b. 1908)