Causes of Comorbidity
- Anatomic proximity of diseased organs
- Singular pathogenetic mechanism of a number of diseases
- Terminable cause-effect relation between the diseases
- One disease resulting from complications of another
- Pleiotropy
The factors responsible for the development of comorbidity can be chronic infections, inflammations, involutional and systematic metabolic changes, iatrogenesis, social status, ecology and genetic susceptibility.
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