Comba can refer to:
- People
- A saint named Comba, a fusion of two female saints: Columba of Sens and Columba of Spain.
- Paul G. Comba, astronomer
- Rocío Comba, discus thrower
- Places
- Santa Comba (disambiguation), the name of several places in Iberia
- Comba, Goa
- In space
- 7636 Comba