Criticisms
It has been claimed that the Columnmaster 4000 has issues with sterility. Due to the rubber nature of the tubes used, the adhesion of proteins is thought to be a possible source of contamination. Other criticisms include the lack of an auto-off feature. The addition of such a feature would allow the user to be sure that the column material would not go dry, and thus, eliminate the risk of large-scale protein loss.
References
1) http://hhmi.wooster.edu/COWJRERE/OverviewERE-08.html 2) Roe, S. "Protein Purification Applications" Oxford University Press. 2001. 3) http://www.proteinscience.org/cgi/content/full/17/4/736
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