Shedding
Collagen XVII is constitutively shed from the keratinocyte surface within NC16A domain by TACE (TNF-Alpha Converting Enzyme), metalloproteinase of the ADAM family. The shedding is lipid raft dependent. Collagen XVII is extracellularly phosphorylated by ecto-casein kinase 2 within the NC16A domain, phosphorylation negatively regulates ectodomain shedding.
Read more about this topic: Collagen, Type XVII, Alpha 1
Famous quotes containing the word shedding:
“The sin of slavery is one of which it may be said that without the shedding of blood there is no remission.”
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