Shedding
Collagen XVII is constitutively shed from the keratinocyte surface within NC16A domain by TACE (TNF-Alpha Converting Enzyme), metalloproteinase of the ADAM family. The shedding is lipid raft dependent. Collagen XVII is extracellularly phosphorylated by ecto-casein kinase 2 within the NC16A domain, phosphorylation negatively regulates ectodomain shedding.
Read more about this topic: Collagen, Type XVII, Alpha 1
Famous quotes containing the word shedding:
“Thus Winter falls,
A heavy gloom oppressive o’er the world
Through Nature shedding influence malign,
And rouses up the seeds of dark disease.
The soul of man dies in him, loathing life,
And black with more than melancholy views.”
—James Thomson (1700–1748)
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Words spoken in the heat of passion, that might have been retracted in good time,
All good intentions, all that was arguable.”
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“The sin of slavery is one of which it may be said that without the shedding of blood there is no remission.”
—James A. Garfield (1831–1881)