Shedding
Collagen XVII is constitutively shed from the keratinocyte surface within NC16A domain by TACE (TNF-Alpha Converting Enzyme), metalloproteinase of the ADAM family. The shedding is lipid raft dependent. Collagen XVII is extracellularly phosphorylated by ecto-casein kinase 2 within the NC16A domain, phosphorylation negatively regulates ectodomain shedding.
Read more about this topic: Collagen, Type XVII, Alpha 1
Famous quotes containing the word shedding:
“Persephone herself is but a voice
or a darkness invisible enfolded in the deeper dark
of the arms Plutonic, and pierced with the passion of dense gloom,
among the splendor of torches of darkness, shedding darkness on the
lost bride and her groom.”
—D.H. (David Herbert)
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A heavy gloom oppressive o’er the world
Through Nature shedding influence malign,
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And black with more than melancholy views.”
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Words spoken in the heat of passion, that might have been retracted in good time,
All good intentions, all that was arguable.”
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