Shedding
Collagen XVII is constitutively shed from the keratinocyte surface within NC16A domain by TACE (TNF-Alpha Converting Enzyme), metalloproteinase of the ADAM family. The shedding is lipid raft dependent. Collagen XVII is extracellularly phosphorylated by ecto-casein kinase 2 within the NC16A domain, phosphorylation negatively regulates ectodomain shedding.
Read more about this topic: Collagen, Type XVII, Alpha 1
Famous quotes containing the word shedding:
“Persephone herself is but a voice
or a darkness invisible enfolded in the deeper dark
of the arms Plutonic, and pierced with the passion of dense gloom,
among the splendor of torches of darkness, shedding darkness on the
lost bride and her groom.”
—D.H. (David Herbert)
“Such is the remorseless progression of human society, shedding lives and souls as it goes on its way. It is an ocean into which men sink who have been cast out by the law and consigned, with help most cruelly withheld, to moral death. The sea is the pitiless social darkness into which the penal system casts those it has condemned, an unfathomable waste of misery. The human soul, lost in those depths, may become a corpse. Who shall revive it?”
—Victor Hugo (1802–1885)
“Thus Winter falls,
A heavy gloom oppressive o’er the world
Through Nature shedding influence malign,
And rouses up the seeds of dark disease.
The soul of man dies in him, loathing life,
And black with more than melancholy views.”
—James Thomson (1700–1748)