Influences of Cohn Process
The Cohn process was a major development in the field of blood fractionation. It has several practical uses in treating diseases such as hepatitis and polio. It was most useful during the Second World War where soldiers recovered at a faster rate because of the transfusions with albumin. The Cohn Process has been modified over the years as seen above. In addition, it has influenced other processes with the blood fractionation industry. This has led to new forms of fractionation such as chromatographic plasma fractionation in ion exchange and albumin finishing processes. In general, the Cohn Process and its variations have given a huge boost to and serve as a foundation for the fractionation industry to this day.
However, the process has not been studied well because it is archaic. Most importantly, it has never been modernized by manufacturing companies. In addition, the conventional process can be environmentally unfriendly because ethanol is a highly explosive substance. It is unsanitary because of the open vessels and tanks, thus the possibility of contamination is high. The cold ethanol format may be too gentle to kill off certain viruses that require heat inactivation. Since this process remains unchanged for so long, several built in inefficiencies and inconsistencies affect the economics of the process for pharmaceutical and manufacturing companies.
Nevertheless, this process still serves as a major foundation for the blood industry in general and its influence can be seen at it is referred to in the development of newer methods. Although it has its drawbacks depending on the variation, the Cohn Process’ main advantage is its practical uses and its utility within pharmacological and medical industries.
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