CMPK

Identifiers Symbols CMPK1; CMK; CMPK; UMK; UMP-CMPK; UMPK External IDs OMIM: 191710 MGI: 1913838 HomoloGene: 32308 ChEMBL: 5681 GeneCards: CMPK1 Gene EC number 2.7.4.14

Gene Ontology
Molecular function	• cytidylate kinase activity • uridine kinase activity • ATP binding • phosphotransferase activity, phosphate group as acceptor
Cellular component	• nucleus • cytoplasm • cytosol
Biological process	• UMP biosynthetic process • pyrimidine ribonucleotide biosynthetic process • nucleobase-containing small molecule interconversion • small molecule metabolic process • nucleobase-containing small molecule metabolic process
Sources: Amigo / QuickGO

RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 51727 66588 Ensembl ENSG00000162368 ENSMUSG00000028719 UniProt B2R6S5 Q9DBP5 RefSeq (mRNA) NM_001136140 NM_025647 RefSeq (protein) NP_001129612 NP_079923 Location (UCSC) Chr 1:
47.8 – 47.84 Mb Chr 4:
114.96 – 114.99 Mb PubMed search

UMP-CMP kinase is an enzyme that in humans is encoded by the CMPK1 gene.

Uridine monophosphate (UMP)/cytidine monophosphate (CMP) kinase (EC 2.7.4.4) catalyzes the phosphoryl transfer from ATP to UMP, CMP, and deoxy-CMP (dCMP), resulting in the formation of ADP and the corresponding nucleoside diphosphate. These nucleoside diphosphates are required for cellular nucleic acid synthesis.