In enzymology, a CMP-N-acylneuraminate phosphodiesterase (EC 188.8.131.52) is an enzyme that catalyzes the chemical reaction
Thus, the two substrates of this enzyme are CMP-N-acylneuraminate and H2O, whereas its two products are CMP and N-acylneuraminate.
This enzyme belongs to the family of hydrolases, specifically those acting on phosphoric diester bonds. The systematic name of this enzyme class is CMP-N-acylneuraminate N-acylneuraminohydrolase. Other names in common use include CMP-sialate hydrolase, CMP-sialic acid hydrolase, CMP-N-acylneuraminic acid hydrolase, cytidine monophosphosialic hydrolase, cytidine monophosphosialate hydrolase, cytidine monophosphate-N-acetylneuraminic acid hydrolase, and CMP-N-acetylneuraminate hydrolase.