Clune is a surname and may refer to:
- Conor Clune (1893 - 1920), Bloody Sunday casualty
- Deirdre Clune (born 1959), Irish politician
- Don Clune (born 1952), American football player
- Frank Clune (1893 – 1971), Australian writer
- Henry W Clune, journalist and novelist
- Jackie Clune (born 1966), comedienne/singer/writer/broadcaster
- John J. Clune, former Director of Athletics at the United States Air Force Academy
- Patrick Clune (1865 - 1935), first Archbishop of the Roman Catholic Church archdiocese of Perth, Western Australia
- Richard Clune (born 1987), Canadian ice hockey player
- Wally Clune (born 1931), retired Canadian ice hockey player