Function
When the catalytic threonine residue of glucosyltransferase deactivates a family of small GTPases,e.g. the Rho family; Rac, and Cdc42 inside the target cells disturb signal transduction mechanisms which leads to dysfunctioning of actin cytoskeleton, cell-cell junction, and apoptosis (Fig. 5). Rho induces the activity of actin stress fibers. Rac proteins controls the activities of membrane ruffling and NADPH-oxidase neutrophil. Cdc42 regulates the F-actin filament formation in filopodia.
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““... The state’s one function is to give.
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Its petals loosen and are strown;
And that’s a fate it can’t evade
Unless ‘twould rather wilt than fade.””
—Robert Frost (1874–1963)
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—Erich Fromm (1900–1980)