Four Predictions of The Clonal Selection Hypothesis
- Each lymphocyte bears a single type of receptor with a unique specificity (by V(D)J recombination).
- Receptor occupation is required for cell activation.
- The differentiated effector cells derived from an activated lymphocyte will bear receptors of identical specificity as the parental cell.
- Those lymphocytes bearing receptors for self molecules will be deleted at an early stage.
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