Moore's estate, Chelsea, was on the west side of Manhattan island above Houston Street, where the developed city ended at the time, and was mostly open countryside. It was once the property of Maj. Thomas Clarke, Clement's maternal grandfather and a retired British veteran of the French and Indian War. Clarke named his house for a hospital in London that served war veterans. The estate was later inherited by Thomas Clarke's daughter, Charity Clarke Moore, and ultimately by grandson Clement and his family.
When New York City laid down the street grid called for in the Commissioner's Plan of 1811, the new Ninth Avenue went through the middle of the estate, causing Moore to write and publish a pamphlet which called on other "Proprietors of Real Estate" to fight the continued development of the city, which he saw as a conspiracy designed to increase political patronage and appease the city's working class. He also decried having to pay taxes for public works such as creating new streets, which he called "a tyranny no monarch in Europe would dare to exercise."
Despite his protests against urban development, eventually Moore began to develop Chelsea, dividing it up into lots along Ninth Avenue and selling them to well-heeled New Yorkers. He also donated to the Episcopal diocese an apple orchard consisting of 66 tracts for use as a seminary, construction on which began in 1827. This became the General Theological Seminary, where Moore served as the first professor of Oriental Languages, and which still survives on the same site, taking up most of the block between 20th and 21st Streets and Ninth and Tenth Avenues. Ten years later, Moore also gave land on Ninth and 20th Street, east of the avenue, for St. Peter's Episcopal Church.
Today, the Manhattan neighborhood which emerged from Moore's ancestral estate is still called Chelsea.
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