Class I PI 3-kinases - Class IA PI 3-kinases

Class IA PI 3-kinases

Class IA PI 3-kinases are activated by receptor tyrosine kinases (RTKs).

There are three catalytic subunits that are classified as class IA PI 3-kinases:

  • p110α
  • p110β
  • p110δ

There are currently five regulatory subunits that are known to associate with class IA PI 3-kinases catalytic subunits:

  • p85α and p85β
  • p55α and p55γ
  • p50α

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